ATG4B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ATG4B antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ATG4B.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	ATG4B antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 43 kDa; Observed: 44 kDa
Gene Name	autophagy related 4B cysteine peptidase
Database Link	NP_037457 Entrez Gene 66615 MouseEntrez Gene 316640 RatEntrez Gene 23192 Human UniProt ID Q9Y4P1
Background	Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4B, also known as AUTL1, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3). ATG4 is required for ATG8 conjugation to phosphatidylethanolamine on autophagosomal membranes. In mammals, each ATG4 homolog shows a selective preference for the ATG8 homologs (4). ATG4B has been found to be a novel protective protein in inflammatory colitis (5).
Synonyms	APG4B; AUTL1
Reference Data
Protein Families	Protease
Protein Pathways	Regulation of autophagy

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