RNF70 (PJA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PJA1 antibody was raised against a 19 amino acid peptide near the amino terminus of human PJA1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	PJA1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 71 kDa; Observed: 71 kDa
Gene Name	praja ring finger ubiquitin ligase 1
Database Link	NP_660095 Entrez Gene 64219 Human UniProt ID Q8NG27
Background	Ubiquitinization is an important cellular degradation process requiring sequential reactions that are mediated by three enzymes: E1, E2 and E3. PJA1, also known as Praja1 and RING finger protein 70, is a 643 amino acid E2-dependent E3-ubiquitin ligase that is abundantly expressed in the brain (1,2). Through interaction and activation with the E2-ubiquitin ligase UBC4, PJA1 mediates substrate-specific ubiquitination via its RING finger domain and facilitates ubiquitination (3). Overexpression of PJA1 in gastrointestinal cancers suggests that it may be responsible for the degradation of some anti-oncogenic proteins (4,5).
Synonyms	BIgR; IGSF4B; Necl-1; NECL1; synCAM3; TSLL1
Reference Data

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