KIBRA (WWC1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	WWC1 antibody was raised against an 18 amino acid peptide near the amino terminus of human WWC1.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	WWC1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 123 kDa; Observed: 110 kDa
Gene Name	WW and C2 domain containing 1
Database Link	NP_001155133 Entrez Gene 23286 Human UniProt ID Q8IX03
Background	The WW and C2 domain containing 1 (WWC1) protein, also known as KIBRA, possesses two WW domains and an internal C2-like domain (1). WWC1 was originally identified as a memory performance-associated protein in humans (2) and has recently been shown to be a novel regulator of the Hippo pathway (3). WWC1 is phosphorylated by the mitotic kinases Aurora-A and ?? (4), and in turn activates the Aurora kinases and is required for precise chromosome alignment during mitosis (5).
Synonyms	PACS-2; PACS1L
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.