MYO7B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Nephrin antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Nephrin.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Nephrin antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 125, 137 kDa; Observed: 125 kDa
Gene Name	myosin VIIB
Database Link	NP_004637 Entrez Gene 4648 Human UniProt ID O60500
Background	Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth (1). Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm (2,3).
Synonyms	DKFZp686A08248
Reference Data

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