NOX3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	NOX3 antibody was raised against a 15 amino acid peptide near the amino terminus of human NOX3.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	NOX3 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 62 kDa; Observed: 72 kDa
Gene Name	NADPH oxidase 3
Database Link	NP_056533 Entrez Gene 50508 Human UniProt ID Q9HBY0
Background	The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith (2,3). It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss (4).
Synonyms	KOX; KOX-1; RENOX
Reference Data

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