Ku70 (XRCC6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Ku70/80 Antibody: A synthesized peptide derived from human Ku70/80
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	70, 82 kDa
Gene Name	X-ray repair complementing defective repair in Chinese hamster cells 6
Database Link	NP_001460 Entrez Gene 14375 MouseEntrez Gene 25019 RatEntrez Gene 2547 Human UniProt ID P12956
Background	The Ku autoantigen is a heterodimer of 70kDa (p70) and 80kDa (p80) proteins. The p70 / p80 dimer is important for function of a 460kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. The Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Synonyms	CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Note	Ku70/80 Antibody detects endogenous levels of total Ku70/80
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Non-homologous end-joining

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