EZH2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-EZH2 Antibody: A synthesized peptide derived from human EZH2
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	85 kDa
Gene Name	enhancer of zeste 2 polycomb repressive complex 2 subunit
Database Link	NP_004447 Entrez Gene 14056 MouseEntrez Gene 312299 RatEntrez Gene 2146 Human UniProt ID Q15910
Background	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Synonyms	ENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2
Note	EZH2 Antibody detects endogenous levels of total EZH2
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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