AIRE Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:3000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-AIRE Antibody: A synthesized peptide derived from human AIRE
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Affinity-chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	autoimmune regulator
Database Link	NP_000649 Entrez Gene 11634 MouseEntrez Gene 326 Human UniProt ID O43918
Background	AIRE Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'.
Synonyms	AIRE1; APECED; APS1; APSI; PGA1
Note	AIRE antibody detects endogenous levels of total AIRE
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Primary immunodeficiency, Ubiquitin mediated proteolysis

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