HEC1 (NDC80) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:3000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-HEC1 Antibody: A synthesized peptide derived from human HEC1
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Affinity-chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	73 kDa
Gene Name	NDC80, kinetochore complex component
Database Link	NP_006092 Entrez Gene 67052 MouseEntrez Gene 10403 Human UniProt ID O14777
Background	HEC1 plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores.
Synonyms	HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3
Note	HEC1 antibody detects endogenous levels of total HEC1
Reference Data
Protein Families	Druggable Genome

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