NCoR (NCOR1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:3000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-NCoR1 Antibody: A synthesized peptide derived from human NCoR1
Isotype	IgG
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Affinity-chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	270 kDa
Gene Name	nuclear receptor corepressor 1
Database Link	NP_001177367 Entrez Gene 20185 MouseEntrez Gene 9611 Human UniProt ID O75376
Background	N-CoR1 is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9.
Synonyms	hN-CoR; N-CoR; N-CoR1; PPP1R109; TRAC1
Note	NCoR1 antibody detects endogenous levels of total NCoR1
Reference Data
Protein Families	Druggable Genome

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