KDM5B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA (1:100 ?? 1:200) ; Western blotting (1:500)
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Jarid1b antibody: mouse Jarid1b (Jumonji, AT rich interactive domain 1B), using a KLH-conjugated synthetic peptides containing an amino acid sequence from the central part of the protein.
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lysine demethylase 5B
Database Link	NP_006609 Entrez Gene 10765 Human UniProt ID Q9UGL1
Background	JARID1B (UniProt/Swiss-Prot entry Q9UGL1) is a histone demethylase which specifically demethylates mono-, di, and trimethylated lysine 4 of histone H3. It acts as a transcriptional repressor for the tumor suppressor genes BRCA1 and HOXA5 and has been associated with breast cancer development. In contrast, in melanoma JARID1B itself may function as a tumor suppressor.
Synonyms	CT31; JARID1B; PLU-1; PLU1; PPP1R98; PUT1; RBBP2H1A
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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