ASH2L Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blotting (1:1,000)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-ASH2 antibody: human Ash2 (absent, small, or homeotic 2), using a recombinant protein.
Isotype	IgG
Concentration	lot specific
Purification	Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ASH2 like histone lysine methyltransferase complex subunit
Database Link	NP_004665 Entrez Gene 9070 Human UniProt ID Q9UBL3
Background	ASH2 (UniProtKB/Swiss-Prot entry Q9UBL3) is a component of the SET1/ASH2 histone methyltransferase (HMT) complex. This complex specifically methylates K4 of histone H3, thereby activating transcription. Methylation of K4 is blocked by premethylation of the neighboring K9, a repressor of transcription. This indicates that the SET1/ASH2 HMT complex mediates the crosstalk between K9 methylation and K4 methylation. ASH2 plays a role in hematopoiesis and may be associated with some kinds of leukemia.
Synonyms	ASH2; ASH2L1; ASH2L2; Bre2
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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