ASH2L Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, WB
Recommend Dilution	ELISA (1:100 ?? 1:500) ; Western blotting (1:500 - 1:1,000); IF: (1:200)
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-ASH2 antibody: mouse Ash2 (absent, small, or homeotic 2), using 3 different KLH-conjugated synthetic peptides, 2 containing an amino acid sequence from the central and 1 containing an amino acid sequence from the C-terminal part of
Isotype	IgG
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ASH2 like histone lysine methyltransferase complex subunit
Database Link	NP_004665 Entrez Gene 23808 Mouse UniProt ID Q9UBL3
Background	Ash2 (UniProtKB/Swiss-Prot entry Q9UBL3) is a component of the Set1/Ash2 histone methyltransferase (HMT) complex. This complex specifically methylates K4 of histone H3, thereby activating transcription. Methylation of K4 is blocked by premethylation of the neighboring K9, a repressor of transcription. This indicates that the Set1/Ash2 HMT complex mediates the crosstalk between K9 methylation and K4 methylation. Ash2 plays a role in hematopoiesis and may be associated with some kinds of leukemia.
Synonyms	ASH2; ASH2L1; ASH2L2; Bre2
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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