Ku70 (XRCC6) Mouse Monoclonal Antibody [Clone ID: 7B1-E12-G4]

Specifications

Product Data
Clone Name	7B1-E12-G4
Applications	IF, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:200
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for XRCC6 antibody: purified recombinant human Ku70 protein fragments expressed in E.coli.
Isotype	IgG1
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	67 kDa
Gene Name	X-ray repair complementing defective repair in Chinese hamster cells 6
Database Link	NP_001460 Entrez Gene 2547 Human UniProt ID P12956
Background	The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
Synonyms	CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Non-homologous end-joining

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