RPA70 (RPA1) Mouse Monoclonal Antibody [Clone ID: 8C3-D12-H10]

Specifications

Product Data
Clone Name	8C3-D12-H10
Applications	IF, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:100
Reactivity	Human, Monkey, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for RPA70 antibody: purified recombinant human RPA70 protein fragments expressed in E.coli.
Isotype	IgG2a
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	70 kDa
Gene Name	replication protein A1
Database Link	NP_002936 Entrez Gene 68275 MouseEntrez Gene 287524 RatEntrez Gene 6117 Human UniProt ID P27694
Background	Plays an essential role in several cellular processes in DNA metabolism including replication,recombination and DNA repair.Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair;it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Synonyms	HSSB; MST075; REPA1; RF-A; RP-A; RPA70
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	DNA replication, Homologous recombination, Mismatch repair, Nucleotide excision repair

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