PDHA1 Mouse Monoclonal Antibody [Clone ID: 3H2-F8-B5]

Specifications

Product Data
Clone Name	3H2-F8-B5
Applications	IF, WB
Recommend Dilution	WB: 1:1000, IF: 1:100
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for PDHA1 antibody: purified recombinant human Pyruvate Dehydrogenase protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	pyruvate dehydrogenase (lipoamide) alpha 1
Database Link	NP_000275 Entrez Gene 18597 MouseEntrez Gene 5160 Human UniProt ID P08559
Background	The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	PDHA; PDHAD; PDHCE1A; PHE1A
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Butanoate metabolism, Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Metabolic pathways, Pyruvate metabolism, Valine, leucine and isoleucine biosynthesis

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