HMG1 (HMGB1) Mouse Monoclonal Antibody [Clone ID: 19N12A1]

Specifications

Product Data
Clone Name	19N12A1
Applications	FC, Simple Western, WB
Recommend Dilution	Western Blot: 1 - 3 ug/mL, Simple Western: 1:100, Flow Cytometry
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length recombinant human HMGB1 was used as the immunogen. full length recombinant (inhouse)
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	high mobility group box 1
Database Link	NP_002119 Entrez Gene 15289 MouseEntrez Gene 3146 Human UniProt ID P09429
Background	HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.
Synonyms	HMG1; HMG3; SBP-1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Base excision repair

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