HEY1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 2-4ug/ml
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 50-100 of mouse Hey1 was used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	hes related family bHLH transcription factor with YRPW motif 1
Database Link	NP_001035798 Entrez Gene 15213 Mouse UniProt ID Q9Y5J3
Background	Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
Synonyms	BHLHb31; CHF2; HERP2; HESR1; hHRT1; HRT-1; OAF1
Note	This antibody has been tested in Western blot on mouse tissue. The Western blot results on human tissue have been mixed.
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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