EIF2A Mouse Monoclonal Antibody [Clone ID: 3A7B11]

Specifications

Product Data
Clone Name	3A7B11
Applications	FC, ICC/IF, IHC, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence, Western Blot: 1:500 - 1:2000, Flow Cytometry: 1:200 - 1:400, Immunohistochemistry: 1:50 - 1:200, Immunohistochemistry-Paraffin: 1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partial recombinant human EIF2A (between residues 350-585) expressed in E. coli [Uniprot Q9BY44]
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	eukaryotic translation initiation factor 2A
Database Link	NP_114414 Entrez Gene 83939 Human UniProt ID Q9BY44
Background	eIF-2 alpha (also known as eukaryotic translation initiation factor 2, subunit 1 alpha) is a 35 kD member of the eukaryotic translation initiation factor 2 family. This cytoplasmic protein is ubiquitously expressed and can downregulate protein synthesis when phosphorylated by PKR kinase under stress conditions (hypoxia, viral infection, ER stress). Increased expression of eIF-2 alpha has been linked to progression of thyroid carcinoma.Signaling inhibited by p58 (IPK) and PKR phosphorylation. Can attenuate the unfolded protein response and inhibits translation. This protein has been shown to interact with eIF2B alpha, eIF2B delta, eIF2B beta subunit 2, p67, p68, and PKR. eIF-2 alpha is a target for cleavage by caspase 3, caspase 6, caspase 8, and caspase 10.
Synonyms	CDA02; EIF-2A; MST089; MSTP004; MSTP089
Reference Data

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