SPIB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 3-5 ug/ml
Reactivity	Human, Mouse, Bovine, Canine, Equine, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acid 15-65 of human Spi-B was used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Spi-B transcription factor
Database Link	NP_003112 Entrez Gene 272382 MouseEntrez Gene 6689 Human UniProt ID Q01892
Background	Transcription factor Spi-B belongs to the ETS family and contains one ETS DNA-binding domain. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression, thus maintains activity of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation. It is reported that Spi-B regulates Progressive multifocal leukoencephalopathy (PML) causing JCVirus gene expression, and may play an important role in JCV activity in the immune and nervous systems. It is also reported Spi-B is expressed in various murine and hematopoietic lines except T lymphoid lines.
Synonyms	SPI-B
Reference Data
Protein Families	Transcription Factors

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