Lin28 (LIN28A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunohistochemistry: 1:1000, Immunocytochemistry/ Immunofluorescence: 10-15 ug/ml, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:1000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Partial recombinant human Lin28 protein expressed in E. coli. [Swiss-Prot# Q9H9Z2]
Formulation	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lin-28 homolog A
Database Link	NP_078950 Entrez Gene 83557 MouseEntrez Gene 79727 Human UniProt ID Q9H9Z2
Background	Lin28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Lin28 is a marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. Lin28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells.
Synonyms	CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1
Note	This Lin28 antibody is useful for IHC-P, ICC/IF and Western blot.
Reference Data
Protein Families	Transcription Factors

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