Macrophage Scavenger Receptor I (MSR1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, ICC/IF, IHC, WB
Recommend Dilution	Proximity Ligation Assay, Immunohistochemistry, Western Blot: 0.5 ug/ml, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Immunohistochemistry-Frozen, Flow Cytometry: 2-5 ug/million cells
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide made to an internal portion of human Macrophage Scavenger Receptor I (within residues 400-450). [Swiss-Prot# P21757]
Formulation	PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50 kDa
Gene Name	macrophage scavenger receptor 1
Database Link	NP_619729 Entrez Gene 20288 MouseEntrez Gene 4481 Human UniProt ID P21757
Background	Macrophage Scavenger Receptor I (MSR1, also called CD204 or scavenger receptor A) belongs to scavenger receptor A family and represents phagocytic pattern-recognition receptors (PRRs) expressed predominantly on macrophages and dendritic cells. MSR1 is a single-pass type II membrane glycoprotein capable of binding to a wide range of polyanionic ligands (e.g., modified low density lipoproteins, pathogen-derived molecules), and is implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis, innate immune response as well as Alzheimer's disease. MSR1 mediates the endocytosis of a diverse group of macromolecules including modified LDLs, and scavenger receptors MSR1, CD36 and LOX-1 are three main receptors for oxidized LDL on macrophage membrane wherein MSR1/CD36 account for more than 9/10 of the lipid accumulation in macrophages exposed to oxidized LDL. Defects in MSR1 have also been linked to prostate cancer and Barrett esophagus (BE).
Synonyms	CD204; phSR1; phSR2; SCARA1; SR-A; SRA
Note	This Macrophage Scavenger Receptor I antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~50 kDa.
Reference Data
Protein Families	Druggable Genome, Transmembrane

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