PEN2 (PSENEN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IP, WB
Recommend Dilution	Immunoprecipitation: 1:50-1:100, Western Blot: 1:1000-1:2500
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-terminus of human PEN2 (within residues 50-101). [UniProt# Q9NZ42]
Formulation	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	12 kDa
Gene Name	presenilin enhancer gamma-secretase subunit
Database Link	NP_758844 Entrez Gene 66340 MouseEntrez Gene 55851 Human UniProt ID Q9NZ42
Background	PEN2 (gamma-secretase subunit PEN-2 or presenilin enhancer protein 2) is an essential subunit of the gamma-secretase complex which is an endoprotease complex responsible for catalyzing the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Gamma-secretase complex is composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. PEN2 represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. PEN2 is a multi-pass membrane protein predominantly localized in the endoplasmic reticulum and in the Golgi stack membrane/cis-Golgi. Defects in PEN2 have been linked to familial acne inversa type 2 (ACNINV2), a chronic relapsing inflammatory disease of the hair follicles which is primarily characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars.
Synonyms	MDS033; MSTP064; PEN-2; PEN2
Note	This PEN2 antibody is useful for Immunoprecipitation and Western blot, where a band can be seen at approximately 12 kDa. This antibody has primarily been tested in HA-PEN2 transfected cells combining Immunoprecipitation with Western blot analysis (ECL). For endogenous sample testing, it is suggested that the investigator load a greater amount of protein on the gel and to combine Immunoprecipitation with Western blot analysis.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Alzheimer's disease, Notch signaling pathway

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