MD2 (LY96) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry: 1:10-1:500, Western Blot: 0.5-2 ug/ml, Immunohistochemistry-Paraffin: 5-10 ug/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A full length recombinant protein was used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lymphocyte antigen 96
Database Link	NP_056179 Entrez Gene 17087 MouseEntrez Gene 448830 RatEntrez Gene 23643 Human UniProt ID Q9Y6Y9
Background	MD2 is a secreted glycoprotein associating with the extracellular domain of Toll-like receptor 4 (TLR4) and trafficking to and from the cell surface and the Golgi apparatus. It has a signal peptide, two N terminal glycosylation sites, and seven Cys residues and consists of a heterogeneous collection of disulfide-linked oligomers. MD2 is an essential accessory glycoprotein required for LPS recognition and associates with toll-like receptor 4 on the cell surface to confer responsiveness to lipopolysaccyaride (LPS), and hence provides a link between the receptor and LPS signaling. It can also function as a soluble receptor for cells that do not otherwise express it. MD2 contains multiple trypsin cleavage sites and its expression is correlated inversely with trypsin activity.
Synonyms	ESOP-1; ly-96; MD-2; MD2
Reference Data
Protein Families	Secreted Protein
Protein Pathways	Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway

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