PLK1 Rabbit Polyclonal Antibody

CAT#: TA336437

Rabbit Polyclonal PLK1 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 200 ul

Product images

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Specifications

Product Data
Applications ICC/IF, IHC, WB
Recommend Dilution Immunohistochemistry, Western Blot: 1:1000-1:2000, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence
Reactivity Human, Mouse, Rat, Bovine, Canine, Porcine, Primate
Host Rabbit
Clonality Polyclonal
Immunogen A portion of amino acids 100-200 of human PLK1 was used as the immunogen.
Formulation Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Whole antisera
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name polo like kinase 1
Background Polo related kinase (PLK), a serine/threonine kinase is strongly correlated with the mitotic activity of cells. PLK is present in all tissues during mouse embryonic development, where as in adults expresion is limited to thymus and ovaries. It has been observed that tumors of various origin (lung, colon, stomach, smooth muscle, and esophagus as well as non-Hodgkin lymphomas) express high levels of PLK transcripts with absent of transcripts in normal surrounding tissues. Only normal colon and placenta, which are known to be mitotically active express PLK. PLK expression is restricted to proliferating cells. In mammalian cells, three PLKs (PLK1, PLK2/Snk, PLK3/Fnk) have been identified. PLK1 is the most studied isoform. The known substrates of PLK1 include several proteins involved in mitosis such as Cdc25C, APC, and cyclin B. PLK1 promotes mitosis through the phosphorylation and activation of Cdc25C, which regulates the tyrosine dephosphorylation of CDKs.
Synonyms PLK; STPK13
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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