UGT (UGT1A1) Rabbit Polyclonal Antibody
CAT#: TA332982
Rabbit anti-UGT1A1 Polyclonal Antibody
Size: 20 ul
Need it in bulk or conjugated?
Get a free quote
热销推荐
CNY 1999.00
CNY 3280.00
Cited in 2 publications. |
CNY 4840.00
CNY 2900.00
CNY 6650.00
CNY 9998.00
Specifications
Product Data | |
Applications | ELISA, ICC/IF, IHC, WB |
Recommend Dilution | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Formulation | Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 60kDa |
Gene Name | UDP glucuronosyltransferase family 1 member A1 |
Database Link | |
Background | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. |
Synonyms | BILIQTL1; GNT1; HUG-BR1; UDPGT; UDPGT 1-1; UGT1; UGT1A |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
---|
Efflux excretion of bisdemethoxycurcumin-O-glucuronide in UGT1A1-overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 (MRP1) as the glucuronide transporters
,Yang, J;Zhang, B;Qin, Z;Li, S;Xu, J;Yao, Z;Zhang, X;Gonzalez, FJ;Yao, X;,
Biofactors
,PubMed ID 30334318
[UGT1A1]
|
The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells
,Li, S;Xu, J;Yao, Z;Hu, L;Qin, Z;Gao, H;Krausz, KW;Gonzalez, FJ;Yao, X;,
Chem. Biol. Interact.
,PubMed ID 30237061
[UGT1A1]
|
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |