DCTN1 Rabbit Polyclonal Antibody
CAT#: TA332431
Rabbit anti-DCTN1 Polyclonal Antibody
Size: 20 ul
Need it in bulk or conjugated?
Get a free quote
CNY 1999.00
CNY 2700.00
CNY 4840.00
CNY 4840.00
Specifications
Product Data | |
Applications | ELISA, IP, WB |
Recommend Dilution | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 142kDa |
Gene Name | dynactin subunit 1 |
Database Link | |
Background | This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). |
Synonyms | DAP-150; DP-150; P135 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Huntington's disease |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |