SRCAP Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5-10ug/ml
Reactivity	Human, Mouse, Rat, Dog, Pig
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-QEGNDAEAQRREIE, from the internal region (near N Trminus) of the protein sequence according to NP_006653.2
Isotype	IgG
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Snf2-related CREBBP activator protein
Database Link	NP_006653 Entrez Gene 100043597 MouseEntrez Gene 361652 RatEntrez Gene 479773 DogEntrez Gene 10847 Human UniProt ID Q6ZRS2
Background	This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Synonyms	DOMO1; EAF1; FLHS; SWR1
Note	IHC: In paraffin embedded Human Skin shows nuclear staining in some keratinocytes.
Reference Data

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