Cacna1a Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)PSSPERAPGREGPYGRE, corresponding to amino acid residues 865-881 of rat CaV2.1. Intracellular loop between domains II and III.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium voltage-gated channel subunit alpha1 A
Database Link	NP_037050 Entrez Gene 773 HumanEntrez Gene 12286 MouseEntrez Gene 25398 Rat UniProt ID P54282
Background	Voltage dependent Ca2+ channels (Cav channels) are pivotal players in many physiological roles such as secretion, contraction migration and excitation.The voltage dependent calcium channels are composed of several subunits; a1, Ã?, a2d and ?. Cav channels were originally divided into six physiological types: L, N , P, Q, R, and T type.The Cav2.1 (formally named a1A) makes up the a1 poreforming subunit in P/Q type Ca2+ channel family. It is expressed preferentially in the central nervous system where along with Cav2.2 is responsible for pre-synaptic Ca2+ influx and neurotransmitter release.Mutations in the Cav2.1 have been shown to cause several neurological disorders among them are familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6 (SCA6).The involvement of Cav2.1 in synaptic transmission was assessed by using ?-Agatoxin IVA , a specific blocker of the Cav2.1 channel. The blocking sensitivity is dependent on the a subunit isoform and on the splice variant.
Synonyms	APCA; BI; CACH4; CACN3; CACNL1A4; Cav2.1; EA2; FHM; HPCA; MHP; MHP1; SCA6
Reference Data

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