TIMP1 Mouse Monoclonal Antibody [Clone ID: F31P2A5]

Specifications

Product Data
Clone Name	F31P2A5
Applications	WB
Recommend Dilution	WB, IHC, ELISA
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Ovalbumin-conjugated synthetic Peptide FQALGDAADIR
Isotype	IgG1, kappa
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23 kD
Gene Name	TIMP metallopeptidase inhibitor 1
Database Link	NP_003245 Entrez Gene 574348 MonkeyEntrez Gene 7076 Human UniProt ID P01033
Background	TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD. TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes. High levels TIMP-1 protein has been found in several types of cancers including breast cancer and this increase associated with a poor patient prognosis. TIMP-1 has also been implicated in the inhibition of apoptosis, promotion of growth, and process of angiogenesis. TIMP-1 may be useful as a prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1). Clone F31P2A5 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human and monkey TIMP-1.
Synonyms	CLGI; EPA; EPO; HCI; TIMP; TIMP-1
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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