PRDM1 Mouse Monoclonal Antibody [Clone ID: ROS195G]

Specifications

Product Data
Clone Name	ROS195G
Applications	WB
Recommend Dilution	WB, IHC, IP, IF, ELISA
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant GST-blimp-1 protein
Isotype	IgG1
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	98 Kd
Gene Name	PR domain 1
Database Link	NP_001189 Entrez Gene 12142 MouseEntrez Gene 639 Human UniProt ID O75626
Background	Blimp-1 is a 98 Kd protein containing five Kuppel-type zinc finger domains that confer sequence specific DNA binding. It has been postulated to be a master regulator of terminal B cell differentiation. In the BCL-1 lymphoma model of differentiation from mature B cells to plasma cells, ectopic expression of Blimp-1 is sufficient to cause terminal differentiation manifested by loss of surface immunoglobulin, IgM secretion, expression of syndecan-1 and cessation of cell division. Recently, it is reported that Blimp-1 is also involved in T cell differentiation and T cell homeostasis and suppression of IL-2 production.
Synonyms	BLIMP1; PRDI-BF1
Reference Data
Protein Families	Transcription Factors

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