Cytokeratin 8 (KRT8) Mouse Monoclonal Antibody [Clone ID: B22.1&B23.1]

Specifications

Product Data
Clone Name	B22.1&B23.1
Applications	IHC
Recommend Dilution	IHC: 1:100 - 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG1, kappa
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	keratin 8
Database Link	NP_002264 Entrez Gene 3856 Human UniProt ID P05787
Synonyms	CARD2; CK-8; CK8; CYK8; K2C8; K8; KO
Note	Cytokeratins 8 & 18 (CK 8 & 18) can be found in most simple epithelia, e.g. thyroid, female breast, gastrointestinal tract, and respiratory tract. Adenocarcinomas and most non-keratinizing squamous carcinomas will stain with anti-CK 8 & 18, but keratinizing squamous carcinomas will not. This antibody is used when attempting to demonstrate the presence of Paget cells; there is very little keratin 18 in the normal epidermis so this will only stain Paget cells. The use of immunostaining facilitates the interpretation and has been shown to be more sensitive than mucin histochemistry.
Reference Data
Protein Families	Druggable Genome

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