CARD4 (NOD1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human NOD1
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	nucleotide binding oligomerization domain containing 1
Database Link	NP_006083 Entrez Gene 107607 MouseEntrez Gene 500133 RatEntrez Gene 10392 Human UniProt ID Q9Y239
Background	Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain (CARD) that is linked to a central nucleotide-binding domain (NBD; also known as a NOD domain) and is followed by carboxy-terminal leucine-rich repeats (LRR). Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9. The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-¦ÊB and JNK pathways. The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-¦ÊB activation in cooperation with the CARD containing kinase, RICK/RIP2/CARDIAK. Mutations in Nod1 have been linked increased susceptibility to asthma and inflammatory bowel disease.
Synonyms	CARD4; CLR7.1; NLRC1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway

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