TPMT Rabbit Polyclonal Antibody
CAT＃: TA326891S
Rabbit anti-TPMT Polyclonal Antibody
Size: 100 ul
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CNY 800.00
货期*
2周
规格
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Specifications
| Product Data | |
| Applications | ELISA, ICC/IF, WB |
| Recommend Dilution | WB,1:500 - 1:2000 IF/ICC,1:10 - 1:100 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
| Predicted Protein Size | 28kDa |
| Gene Name | thiopurine S-methyltransferase |
| Database Link | |
| Background | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. |
| Synonyms | OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Drug metabolism - other enzymes |
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