STEAP3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human STEAP3
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	STEAP3 metalloreductase
Database Link	NP_060704 Entrez Gene 68428 Mouse UniProt ID Q658P3
Background	Caspases modulate apoptosis in various ways. Specifically, Caspase-3, a death protease, is instrumental in cleaving cellular proteins, dismantling the cell and forming apoptotic bodies. pHyde has a potential role as a tumor suppressor by inducing caspase-3-mediated apoptosis and stimulating p53 expression. A dose-dependent increase in caspase-3 activity is observed in transduced pHyde DU145 cells. Furthermore, caspase-3 may be necessary for pHyde-mediated apoptosis. The pHyde gene may upregulate the apoptosis pathway and thus have a potential application in cancer gene therapy. Recombinant pHyde inhibits the growth of human prostate cancer cell lines DU145 and LNCaP in vitro. DU145 tumors may be reduced significantly in vivo when nude mice are injected with recombinant pHyde. pHyde also has a demonstrated growth inhibitory effect on human breast cancer cells. This suggests that pHyde may have a role in inhibiting different tumor types.
Synonyms	AHMIO2; dudlin-2; dudulin-2; pHyde; STMP3; TSAP6
Reference Data
Protein Families	Transmembrane
Protein Pathways	p53 signaling pathway

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