LAMTOR1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Rabbit polyclonal LAMTOR1 antibody was raised against a 17 amino acid peptide near the amino terminus of human LAMTOR1
Isotype	IgG
Formulation	LAMTOR1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	LAMTOR1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 18 kDa; Observed: 18 kDa
Gene Name	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Database Link	NP_060377 Entrez Gene 66508 MouseEntrez Gene 308869 RatEntrez Gene 55004 Human UniProt ID Q6IAA8
Background	LAMTOR1 is a 161 amino acid membrane protein belonging to the LAMTOR family. It has been identified to interact with and recruit the four Rag GTPases (Rag A-D) to the surface of lysosomes (1). The mTORC1 kinase complex is a critical component in the regulation of cell growth (2). As part of the ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids (3). LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes / lysosomes (4).
Synonyms	C11orf59; p18; p27RF-Rho; PDRO; Ragulator1
Reference Data

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