ITCH Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ITCH antibody was raised against a 15 amino acid peptide near the amino terminus of human ITCH
Isotype	IgG
Formulation	ITCH antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	ITCH antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 99 kDa; Observed: 99 kDa
Gene Name	itchy E3 ubiquitin protein ligase
Database Link	NP_001244066 Entrez Gene 83737 Human UniProt ID Q96J02
Background	The Itchy E3 ubiquitin protein ligase (ITCH) is a member of the Nedd4 family of HECT domain E3 ubiquitin ligases (1). HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. ITCH plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses (2). In B cells, ITCH is thought to associate with latent membrane protein 2A (LMP2A) of Epstein-Barr virus, specifically down-regulating its activity in B cell signaling (3). Mutations in this gene are a cause of syndromic multisystem autoimmune disease (4).
Synonyms	ADMFD; AIF4; AIP4; dJ468O1.1; NAPP1
Reference Data

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