Aquaporin 2 (AQP2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	AQP2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AQP2.
Isotype	IgG
Formulation	AQP2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	AQP2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 30 kDa; Observed: 28 kDa
Gene Name	aquaporin 2
Database Link	NP_000477 Entrez Gene 11827 MouseEntrez Gene 25386 RatEntrez Gene 359 Human UniProt ID P41181
Background	Aquaporins are membrane proteins that serve in the transfer of water and small solutes across cellular membranes. One such aquaporin, aquaporin-2 (AQP2) is located in the kidney collecting tubule and plays a critical role in water reabsorbtion (1). AQP2 is mainly localized in intracellular vesicles but upon stimulation with anti-diuretic hormone (ADH), AQP2 is translocated to the apical plasma membrane by exocytic fusion of AQP2-bearing vesicles (2). Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus (3).
Synonyms	AQP-CD; WCH-CD
Reference Data
Protein Families	Druggable Genome, Transmembrane

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