IL28B (IFNL3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	IL-28B antibody was raised against a 17 amino acid peptide near the center of human IL-28B.
Isotype	IgG
Formulation	IL-28B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	IL-28B Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 20 kDa; Observed: 16 kDa
Gene Name	interferon, lambda 3
Database Link	NP_742151 Entrez Gene 282617 Human UniProt ID Q8IZI9
Background	Interleukin 28 (IL-28B), also known as interferon lambda 3, is cytokine distantly related to type I interferons and the IL-10 family (1). The IL-28B gene and the closely related cytokine genes IL-28A and IL-29 form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection and can induce anti-viral activity (2,3). All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor-beta (IL10RB) and interleukin 28 receptor- alpha (IL28RA) (1).
Synonyms	IL-28B; IL28B; IL28C
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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