TBX21 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	TBX21 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human TBX2.
Isotype	IgG
Formulation	TBX21 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TBX21 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 59 kDa; Observed: 55 kDa
Gene Name	T-box 21
Database Link	NP_037483 Entrez Gene 57765 MouseEntrez Gene 30009 Human UniProt ID Q9UL17
Background	TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box (1,2). Members of this family include transcription factors involved in the regulation of developmental processes (2). Studies in mouse and humans show that TBX21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (1,3). Expression of the human ortholog also correlates with interferon-gamma expression in Th1 and natural killer cells, suggesting a TBX21 may play a role in initiating Th1 lineage development from naive Th precursor cells. (3).
Synonyms	T-bet; T-PET; TBET; TBLYM
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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