RIM2 (RIMS2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	RIM2 antibody was raised against a 17 amino acid synthetic peptide near the center of human RIM2.
Isotype	IgG
Formulation	RIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	RIM2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	regulating synaptic membrane exocytosis 2
Database Link	NP_001093587 Entrez Gene 9699 Human UniProt ID Q9UQ26
Background	RIM2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
Synonyms	OBOE; RAB3IP3; RIM2
Reference Data

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