Slc17a7 Mouse Monoclonal Antibody [Clone ID: S28/9]

Specifications

Product Data
Clone Name	S28/9
Applications	WB
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 493-560 (cytoplasmic C-terminus) of rat VGlut1
Isotype	IgG1
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	solute carrier family 17 member 7
Database Link	NP_446311 Entrez Gene 57030 HumanEntrez Gene 72961 MouseEntrez Gene 116638 Rat UniProt ID Q62634
Background	VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesiclesfrom the brain, exhibiting a conductance for chloride that is blocked by glutamate . Vesicular glutamatetransport has a substantially lower apparent affinity than the plasma membrane excitatory amino acidtransporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in thesame range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognizeboth aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate .
Synonyms	BNPI; VGLUT1
Note	Detects ~52kDa. No cross-reactivity against VGlut2.
Reference Data

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