Slc12a5 Mouse Monoclonal Antibody [Clone ID: S1-12]

Specifications

Product Data
Clone Name	S1-12
Applications	WB
Recommend Dilution	IHC: 1:300
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 932-1043 corresponding to rat KCC2
Isotype	IgG2a
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	solute carrier family 12 member 5
Database Link	NP_599190 Entrez Gene 57138 MouseEntrez Gene 57468 HumanEntrez Gene 171373 Rat UniProt ID Q63633
Background	KCC2 is a member of the cation-chloride cotransporter gene family . It acts as a K-Cl cotransporter. KCCsnormally lower intracellular chloride concentrations below the electrochemical equilibrium potential anddepending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a netefflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizingpostsynaptic inhibition in the brain . KCC2 is expressed at high levels in neurons throughout thenervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinalcord . Studies in mice have shown that KCC2 reduces GABAs inhibitory signaling, resulting in motor defects,epilepsy, and anxiety-like behavior.
Synonyms	hKCC2; KCC2; KIAA1176
Note	Detects ~140kDa.
Reference Data

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