Cask Mouse Monoclonal Antibody [Clone ID: S56A-50]

Specifications

Product Data
Clone Name	S56A-50
Applications	IHC, WB
Recommend Dilution	WB: 1:1000
Reactivity	Mouse, Rat, Human, Zebrafish, Xenopus
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 318-415 of rat CASK/Lin2
Isotype	IgG1
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Database Link	NP_071520 Entrez Gene 8573 HumanEntrez Gene 12361 MouseEntrez Gene 29647 Rat UniProt ID Q62915
Background	CASK (calmodulin sensitive kinase) is a ~112kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures . While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator . Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births . CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing .
Synonyms	CAGH39; CMG; FGS4; FLJ22219; FLJ31914; hCASK; LIN2; MICPCH; TNRC8
Note	Detects ~100kDa.
Reference Data

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