HSP90AB1 Mouse Monoclonal Antibody [Clone ID: AC-16]

CAT#: TA326371

Mouse monoclonal Hsp90 Antibody



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CNY 6,017.00


货期*
4周

规格
    • 200 ug

Cited in 1 publication.

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经常一起买 (4)
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Recombinant protein of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), 20 µg
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Recombinant protein of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), 100 µg
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Specifications

Product Data
Clone Name AC-16
Applications IHC
Recommend Dilution 1ug/ml was sufficient for detection of hsp90 by Western Blot in 20ug of HeLa lysate.
Reactivity Human, Rabbit, Rat, Mouse, Chicken, Achyla, Wheat Germ, Sf9 cell line
Host Mouse
Clonality Monoclonal
Immunogen Heat shock protein 900 from the water mold Achyla ambisexualis
Formulation PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name heat shock protein 90kDa alpha family class B member 1
Background Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex . Despite its label of being a heat-shock protein, hsp90 is one of the most highly expressed proteins in unstressed cells (12% of cytosolic protein). It carries out a number of housekeeping functions including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the hsp90-regulated proteins that have been discovered to date are involved in cell signaling . The number of proteins now know to interact with Hsp90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5 When bound to ATP, Hsp90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, hsp90-interacting proteins have been shown to co-precipitate with hsp90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in hsp90 expression or hsp90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit hsp90 function .
Synonyms D6S182; HSP84; HSP90B; HSPC2; HSPCB
Note This antibody is reactive with both the constitutive and the inducible form of Hsp90. It does not bind to the native form and does not recognize Hsp90 from E.coli or yeast.
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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