Calpain 1 (CAPN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-5000 WB positive control: K562, Jurkat and Hela cell lysates IHC: 50-200 Positive control: Human tonsil Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 543-713 amino acids of Human Calpain-1 catalytic subunit
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	82 kDa
Gene Name	calpain 1
Database Link	NP_001185797 Entrez Gene 12333 MouseEntrez Gene 29153 RatEntrez Gene 823 Human UniProt ID P07384
Background	The calpains; calcium-activated neutral proteases; are nonlysosomal; intracellular cysteine proteases. The mammalian calpains include ubiquitous; stomach-specific; and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large; catalytic subunits associated with a common small; regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme; calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
Synonyms	CANP; CANP1; CANPL1; muCANP; muCL; SPG76
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Alzheimer's disease, Apoptosis

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