beta 2 Adrenergic Receptor (ADRB2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-2000 WB positive control: Hela and A549 cells IHC: 15-50 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 21-33 amino acids of Human adrenoceptor beta 2, surface
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46 kDa
Gene Name	adrenoceptor beta 2
Database Link	NP_000015 Entrez Gene 11555 MouseEntrez Gene 154 Human UniProt ID P07550
Background	This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors; the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein; an adenylyl cyclase; cAMP-dependent kinase; and the counterbalancing phosphatase; PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms; point mutations; and/or downregulation of this gene are associated with nocturnal asthma; obesity and type 2 diabetes.?
Synonyms	ADRB2R; ADRBR; B2AR; BAR; BETA2AR
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Calcium signaling pathway, Endocytosis, Neuroactive ligand-receptor interaction

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