p57 Kip2 (CDKN1C) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colorectal cancer Predicted cell location: Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1-14 amino acids of human cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cyclin-dependent kinase inhibitor 1C
Database Link	NP_000067 Entrez Gene 1028 Human UniProt ID P49918
Background	This gene is imprinted; with preferential expression of the maternal allele. The encoded protein is a tight-binding; strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome; suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms	BWCR; BWS; KIP2; p57; p57Kip2; WBS
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle

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