Thyroid Peroxidase (TPO) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	thyroid peroxidase
Database Link	NP_000538 Entrez Gene 7173 Human UniProt ID P07202
Background	This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones; thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis; including congenital hypothyroidism; congenital goiter; and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene; but the full-length nature of some variants has not been determined.
Synonyms	MSA; TDH2A; TPX
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway, Metabolic pathways, Tyrosine metabolism

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