DTX2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-100 Positive control: Human brain Predicted cell location: Cytoplasm and Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 300 amino acids of human deltex homolog 2 (Drosophila)
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	deltex 2, E3 ubiquitin ligase
Database Link	NP_065943 Entrez Gene 74198 MouseEntrez Gene 113878 Human UniProt ID Q86UW9
Background	DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling; a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch; depending on the developmental and cell context. Mediates the antineural activity of Notch; possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro; suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Synonyms	RNF58
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Notch signaling pathway

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